Monday, December 9, 2013

Case of the Week 285

This week's case was generously donated by Dr. Bryan Schmitt and Dr. Ryan Relich (Microbe Man).

An HIV positive man from the U.S. presented with multiple anal and rectal condylomas.  No travel history is available.  Excision with histopathology (H&E staining) showed the following:

(40x total magnification)

(500x total magnification)

(1000x total magnification)

GMS stain:


Anonymous said...

This looks like Leishmania, because I think I see kinetoplasts and I believe Leishmania is negative by GMS. However, I would also consider Microsporidium, but perhaps these forms are too large for microspordia. I thought of microsporidia because perhaps the dark lines in the middle are the polar tubules.

Anonymous said...

I like leishmania too and a distant 2nd choice toxoplasmosis again. GMS means not histoplasmosis although internal structure not that.

Anonymous said...

What's the maginification on these? 100x?

Bobbi Pritt said...

Sorry to have excluded the magnification - it's now been added!

Anonymous said...

The GMS negative excludes Microsporidia, size wise Leishmania and Toxoplasma is in range. The cellular morphology is more consistent with Leishmania. It will be interessting to learn the true identity.

Florida Fan

Anonymous said...


Guillermo Martínez Molina said...