The following sections of placenta are from a still-borne infant with severe growth retardation. On gross examination, the placenta was smaller than normal and had several infarcts. Microscopic examination showed erythrocytes with brown pigment and inclusions, as well as chronic villitis, synctial knotting, and pigment in trophoblastS and WBCs. Diagnosis? For the hematopathologists in the audience, there is another diagnosis present as well...
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4 comments:
So, am I safe in presuming that homozygosity does not provide absolute protection?
Sickle cell trait and malaria.
Yup I agree, PAM but interestingly sickle cell...I wonder as does the first post that this trait does not offer complete immunity.
Being homozygous does offer immunity but it also means that you are homozygous for sickle cell disease and might not make it out of your 20's-30's (depending on where you live and the type of medical treatment you can get).
Duffy blood group negative protects against p. vivax and HLA type B53 has also been shown to be effective in West Africa.
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