A patient with recurrent high grade lymphoma on an extensive chemotherapeutic regimen presented with increasing shortness of breath and consolidation on chest radiograph. Antibiotic therapy was unsuccessful and she expired. Autopsy of the lungs showed the following on hematoxylin and eosin staining (CLICK ON IMAGES TO ENLARGE):
(10x objective, 100x final magnification)
(40x objective, 200x final magnification)
(100x objective, oil immersion, 1000x final magnification)
(100x objective, oil immersion, 1000x final magnification)
(100x objective, oil immersion, 1000x final magnification)
Diagnosis of this unfortunate case?
3 comments:
Acanthamoeba sp.
Country of residence or travel history? Any other organ system (CNS or GI in particular) affected by a similar process?
I admit my first thoughts were of viral cytopathy, but these do in fact resemble some sort of amoebae (which would be extraordinarily unusual pulmonary pathogens).
Interested to see the answer!!!!!
Entamoeba hystolitica from lung's cyst maybe?
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