Monday, August 11, 2025
Sunday, August 10, 2025
Answer to Case of the Week 784
Answer to the Parasite Case of the Week 784: Myiasis causing fly larva, most likely Cuterebra species.
Thankfully, Rebecca Black and her colleagues were able to remove the larva from this poor kitty!
As noted by Florida Fan and others, we don't have the posterior spiracles to make a definitive identification. However, based on the presentation, geographic location, dark color, and overall appearance, we can still make an identification of Cuterebra sp. third instar stage larva.
Note the dark color and small spines covering most of the body.If you are interested, you can read more about this infection in animals at the following excellent sites:
Cuterebra Infestation in Small Animals - Integumentary System - Merck Veterinary Manual
Companion Animal Parasite Council | Cuterebriasis
Genus Cuterebra - Rodent and Lagomorph Bot Flies - BugGuide.Net
The usual hosts of Cuterebra are rodents and lagamorphs. Flies lay eggs on vegetation or woody ground debris, often near the opening of rodent burrows. The eggs hatch to release a first instar stage larva when there is exposure to increased temperature, indicating the presence of a nearby host. The larva then enters host through any natural body opening such as the mouth or existing wounds. It will then migrate to the subcutaneous tissues and enlarges rapidly. It creates a pore from which it can breathe and eventually exit the host, usually in 3-6 weeks.
As you all know, my interest is in human infections, and therefore I posted this case as both a pet lover and a human medical parasitologist. Cuterebra infections (cuterebriasis) can rarely occur in humans, and as with other forms of myiasis, removal of the larva is curative.
Thanks again to student veterinarian, Rebecca Black, for donating this case!
Monday, August 4, 2025
Case of the Week 783
This week's case was generously donated by Dr. Richard Bradbury. The following were seen in a stool specimen from a middle-aged man with diarrhea. Preparations are a concentrated wet prep and trichrome stained permanent mount. Object measure 10-15 micrometers long. What is your identification?
Sunday, August 3, 2025
Answer to Case 783
Answer to the Parasite Case of the Week 783: Chilomastix mesnili cysts and trophozoites. Note the classic morphology:
C. mesnili is a non-pathogenic flagellate and therefore not the cause of this patient's diarrhea.
Thanks again to Dr. Bradbury for donating this great case!
Monday, July 28, 2025
Case of the Week 782
This week's case was generously donated by Dr. Adrienne Showler. The following image is from a video capsule endoscopy performed on an immunocompromised patient with diarrhea. The patient has not travelled outside of the US and has no other risk factors for parasitic infection. Numerous of these objects were seen - none were moving. Identification?
Sunday, July 27, 2025
Answer to Case 782
Answer to the Parasite Case of the Week 782: Not a parasite.
Most closely resembles banana "seeds" (tannin bodies).
While we will never know for sure, the beaded/fragmented appearance and dark color of these objects allow us to identify this as a non-parasitic object that closely resembles banana tannin bodies. You can read more about banana tannin bodies in my previous cases 139 and 468. In particular, I recommend checking out Case 468 which shows my experiment to recreate a partially-digested banana.
Thanks again to Dr. Adrienne Showler for donating this interesting case!
Monday, July 14, 2025
Case of the Week 781
This week's case features a beautiful video from Dr. Rasool Jafari. The specimen is skin scrapings. What is your identification?
Sunday, July 13, 2025
Answer to Case 781
Answer to Parasite Case of the Week 781: Demodex sp. The legs and gnathosoma (with mouthparts) are nicely demonstrated:
Monday, June 30, 2025
Case of the Week 780
This week's case was generously donated by Dr. Manohar Mutnal. The following were seen in a peripheral blood smear from a patient with an unknown travel history. What is your differential diagnosis? What additional information would you like?
Sunday, June 29, 2025
Answer to Case 780
Answer to Parasite Case of the Week 780: Trypanosoma brucei trypomastigotes.
As noted by Florida Fan, "This is definitely a case of trypanosomiasis. The flagellate doesn’t show a prominent kinetoplast nor assume a C shape in general. This rules out Chagas disease caused by T. cruzi. We have Trypanosoma brucei, yet morphology alone doesn’t warrant a differential diagnosis of subspecies gambiense nor rhodesiense."
Idzi also noted that "In the first picture we can clearly see the difference between the two morphologies of T. brucei: the "short stumpy" form (adapted for survival in the tsetse fly vector --> transmission) versus the "long slender" form (which multiplies in the host)!" Here is an annotated version of this image showing these two morphologies:
I had also asked what additional information is needed in this case - and you all responded with excellent suggestions. In summary,
- We first, we need to know the travel history to determine the likely subspecies. PCR could also be performed. This is important for treatment and prognostic implications.
- Second, we need to know the stage of disease, as this will also drive treatment decisions. As noted by Idzi, "A lumbar puncture will be able to tell us if the patient has evolved to stage II of the disease, where the parasite has invaded the central nervous system. Even if no tryps are found in the CSF, a raised number of WBCs in the CSF will still be indicative of stage II disease (when tryps are found in the blood).