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A parasitologist's view of the world
Welcome to Parasite Case of the Week
Every week I will post a new Case, along with the answer to the previous case. Please feel free to write in with your answers, comments, and questions. Also check out my image archive website at http://parasitewonders.com. Enjoy!
The Fine Print:
Please note that all opinions expressed here are mine and not my employer. Information provided is for educational purposes only. It is not intended as and does not substitute for medical advice. I do not accept medical consults from patients.
The Fine Print:
Please note that all opinions expressed here are mine and not my employer. Information provided is for educational purposes only. It is not intended as and does not substitute for medical advice. I do not accept medical consults from patients.
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7 comments:
Looks like human African trypanosomiasis, and with the travel history to East Africa it might specifically be due to Trypanosoma brucei rhodesiense. The most important additional test would be a lumbar puncture for disease staging, which in T. b. rhodesiense is very important given the treatment regimens for the haemolymphatic and meningoencephalitic stages are very different.
LS
Very nice case of trypanosomiasis. With a history of travel to East Africa, my bet is Trypanosoma brucei rhodesiene too. I would concur with LS on the additional testing.
Florida Fan
Gorgeous photos. Would Anonymous tell us what the different treatments would be between for this trypanosome? That would be interesting.
BW,a retired pathologist in Vt
East Africa? Probabilmente Trypanosoma brucei rhodesiense.
Got tryp on a trip? What a trip!
One can always get a rhyme out of Blaine, but not Blaine out of the rhymes.
Florida Fan
Hi BW, I believe the treatment for early stage Rhodesian trypanosomiasis would be suramin, or alternatively pentamidine. But the only treatment for late stage disease is melarsoprol, which is also highly toxic. The latest advances in treatment of African trypanosomiasis have mainly been in Gambian (or Western) trypanosomiasis (T. b. gambiense); these being nifurtimox-eflornithine combination therapy (NECT) and fexinidazole. That being said, the Drugs for Neglected Diseases Initiative (DNDi) is working on clinical trials for fexinidazole for Rhodesian trypanosomiasis.
LS
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